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Senior Mechanical Engineer – Cartridge & Consumables

Senior Mechanical Engineer – Cartridge & Consumables


We are looking for a Mechanical Design Engineer with extensive experience in design for cartridge and regent consumable containers to join our exciting journey into development of synthesis biology platforms. At Nuclera, fast-growing and multidisciplinary teams of microfluidics, protein synthesis, DNA synthesis, biochemistry and engineering collaborate to develop new desktop instruments utilising single use cartridges and consumables to revolutionize gene and protein synthesis. The successful candidate will enable the design, prototyping, testing, optimization and scalability of new device and reagent cartridges and consumables and also contribute in the interfacing elements of these products with our novel synthesis platform that has microfluidics at its core.
This role represents a great opportunity for candidates with the right to work in the UK, in helping to shape the emerging Platform team in the exciting field of biotechnology research instrument development. We are seeking candidates with excellent mechanical design capabilities to help with design of high volume, low-cost, plastic injection moulded devices and reagent supply consumable containers for DNA and protein synthesis applications. The right candidate will have practical experience in offering innovative approaches to product development challenges for production scalability.
Specific responsibilities include but are not limited to:

  • Provide mechanical engineering designs in the development of plastic components and mechanisms primarily for cartridges and consumables in interfacing with the instrument.
  • Improve quality, cost, manufacturability, cleanliness, and reliability of current consumable products through management of suppliers and, if necessary design changes.
  • Collaborate with a cross functional team in the development of the new interfacing elements with the instrument in conjunction with engineering consumable products.
  • Define appropriate tests for consumables, as well as reagent-filling manufacturing workflows.
  • Develop engineering and design documentation in our product data management system.
  • Take ownership of development efforts at sub-system level with effective technical communication with other functions.
  • Source commercially off the shelf components and utilising both in-house fabrication capacity and external vendors for custom designed parts.
  • Prototyping, testing and improving custom designs, by embracing sound experimental methods and hands-on approach in the laboratory and workshop.
  • Develop manufacturing baseline documents such as part and assembly drawing, work instruction and test instruction
  • Attend details, take pride in quality, and ability to deliver iteratively in an agile manner.
  • Interact effectively with other team members to understand and solve the engineering problems that arise.

Required qualifications and skills:

  • Engineering degree at Bachelor or Master degree or the equivalent.
  • At least 5 years of design and development experience using CAD packages, preferably SOLIDWORKS, with demonstrable results.
  • Extensive experience in leading design of injection moulded plastic components and mechanisms.
  • Demonstrate ability to use simulation tools and iterative development (design, prototyping, testing and validation) in liaising with sub-tier manufacturer with strong documentation practices.
  • First-hand knowledge of design for manufacturing and assembly with knowledge of manufacturing baseline transfer.
  • Demonstrate ability to work with internal production or external vendors, and preferably CMO.
  • Demonstrate a ‘can do’ attitude with flexibility to adapt to the needs of the development team.

Desirable qualifications and skills:

  • Experience of full-cycle product development and commercialisation of high volume cartridge and reagent supply containers, requiring strong joining of multiple parts that includes overmoulded hermetic seals.
  • Extensive experience using simulation tools to support design optimisation.
  • Expertise in bonding methods of multiple dissimilar materials (e.g. glass, plastics, rubbers via adhesives, vibration and laser welding).
  • Design for assembly automation methods for low-cost and high volume single use consumables for life science application such as diagnostics and drug delivery.
  • Lab-on-chip device design, ideally for microfluidic devices in diagnostics and point of care products
  • Self-driven and motivated individual with the professional attitude and potential to take a leading role in mechanical engineering.
  • Experience in design for precise control of liquids and chemical compatibility in fluidic systems (ideally microfluidics).
  • Practical understanding to design custom parts for various manufacturing techniques at low and high volume, especially injection moulding of consumable parts.
  • Experience of working in projects with tight timelines, ideally managed through agile frameworks.
  • Extensive experience with PDM, PLM, ERP and QMS systems ideally under ISO13485 environment.
  • Strong communication skills, with positive attitude, drive and collaborative mentality.

In addition to competitive salaries, we offer a range of benefits for all of our colleagues, including:

  • Life Assurance 4x Annual Salary
  • Private Medical insurance and Cash Plan
  • 25 days’ Annual Leave
  • EMI-approved Option Scheme
  • Enhanced employer’s Pension Contributions
  • Enhanced Maternity and Paternity Leave
  • Investment in professional development and learning
  • Access to amenities from the Cambridge Science Park
  • Fresh fruit, tea, coffee and snacks in the office
  • Monthly celebratory cake treats
  • Organised annual events for staff and their families.
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