Enzymology & Protein Engineering Scientist

Oxford, UK
50000 GBP

We are delighted to have partnered with an innovative Oxford based biotech start-up. They are looking for a Protein Engineering/Enzymology Lead Scientist. They were recently acquired by a US based company but have certainly not lost their ‘start-up’ identity.

You’ll be involved in developing this novel and disruptive technology which will have a significant impact on personalised medicine and human health.

The Role

Working with a highly skilled interdisciplinary team you will optimise and characterise enzymatic methods, develop & implement processes and tools to support enzyme manufacturing and identify or create new enzymes or enzyme mutants with improved properties.

You will collaborate highly effectively with the broader R&D team and senior staff on project requirements, planning, execution and reporting. It is expected that you will spend a substantial proportion of your time in the lab

Skills and Experience

  • Post-doctoral experience in protein engineering, expression & purification or enzymology, OR industrial experience.
  • Proven track record of identifying/creating new enzymatic activities and prototype processes required to manufacture and QC them, ideally in the field of molecular biology and DNA analysis.
  • Familiarity with modern methods for enzyme mutagenesis, screening, expression/purification, characterisation and QC.
  • Expertise with a variety of analytical tools used for enzyme characterisation including activity-based assays and current biophysical methods
  • A PhD in Biochemistry, Molecular Biology or similar discipline. Candidates without a PhD but with highly relevant experience should apply.
  • Strong team-working skills with previous experience of completing collaborative projects on time and within budget.
  • Excellent communication skills (both written and oral) with the ability to communicate complex ideas and information to a range of stakeholders.
  • Demonstrable high levels of self-motivation, ambition, transparency and integrity.
  • Enjoy working towards challenging goals in a fast-moving environment where on-time delivery of results is a high priority.


  • Expertise in the study & optimisation of DNA modification enzymes.
  • Experience of RUO or IVD product development processes from concept through development & transfer to manufacturing.
  • Previous experience of working with high throughput genomic analysis tools, especially Next Generation Sequencing.
  • Familiarity with the analysis and interpretation of Next Generation Sequencing Data.
Job Overview
Location : Oxford, UK
Type : Permanent
Category : Biotech
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